The trials measured pounds lost. They said much less about muscle, micronutrients, skin, or the gut — the four things our customers ask about at week six. This page is what we read before we formulated anything, and where we think the evidence is strong versus still thin.
When calorie intake drops sharply, the body draws on both fat and lean tissue. Body-composition analyses of large GLP-1 trials have found that a meaningful share of total weight lost is lean mass — commonly reported in the range of a quarter to nearly 40% depending on the population, the drug, and whether patients were resistance training or hitting protein targets.
That share is not fixed. It responds to two inputs you control: how much protein you eat, and whether you load your muscles. The problem is that a GLP-1 works by removing the appetite you would need to hit the first one.
Typical reduction reported on GLP-1 therapy — the mechanism that makes the drug work.
Upper end of reported lean-mass share in rapid weight loss without adequate protein or training.
The intake range associated with better lean-mass retention during a deficit.
At that intake, hitting a protein target from food alone is arithmetically difficult for most people.
HMB (β-hydroxy-β-methylbutyrate) is a metabolite of leucine studied for decades in populations losing muscle — older adults, bed rest, hospital stays, and athletes in a deficit. The consistent signal across trials and meta-analyses is a reduction in muscle protein breakdown rather than a large increase in muscle growth. That is precisely the mechanism that matters in a caloric deficit.
We use myHMB™, the branded calcium-HMB form used in most of the published literature, at 3g per serving — the dose used in the majority of those studies. It is not a proprietary blend and the amount is on the label.
Where we won't overclaim: to our knowledge there is no published randomized trial of HMB specifically in patients taking GLP-1 receptor agonists. The rationale is mechanistic — same deficit, same breakdown pathway — not a GLP-1-specific outcome trial. Anyone telling you otherwise is ahead of the data.
Adequate protein and resistance training reduce lean-mass loss during weight loss. This is about as settled as nutrition science gets.
HMB supplementation attenuates muscle protein breakdown in catabolic states and deficits. Effect sizes vary by population.
Those findings extend to GLP-1 users, who are in a deficit by design. Untested directly. We say inference, not proof.
That any supplement prevents muscle loss, replaces training, treats a condition, or changes how your medication works.
Micronutrients scale with food volume. Reduce intake by a quarter for six months and the shortfalls that show up first are the ones with the thinnest margins to begin with — vitamin D, B12, iron, and magnesium. Reduced gastric emptying and lower stomach acid can compound absorption on top of lower intake.
These are the labs worth asking your prescriber to run at your six-month visit — not because a supplement fixes a diagnosis, but because you can't manage what nobody measured.
Protein + HMB covers the protein and lean-mass side. The GLP-1 Booster and MetaboLift cover repletion, digestion, and daily comfort. Nothing in the range is a weight-loss product — your prescription already does that job.
We'd rather point you at the literature than summarise it for you. These are the areas of research the formulas draw on. Search any of them and you'll find the trials, the meta-analyses, and the disagreements.
Figures on this page are our summary of a mixed literature, with ranges rather than single numbers where studies disagree. Nothing here is medical advice, a diagnosis, or a claim that our products treat a condition. These statements have not been evaluated by the Food and Drug Administration. Talk to your prescriber before adding anything to a GLP-1 regimen.
Take it every day for 90 days. If you don't feel the difference, email us and we refund every dollar — no return, no restocking fee, no photos of a half-empty bottle. The risk of being wrong sits with us, not you.
†These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.